Treatment

Investigating the clinical relevance of the remaining 15 subtypes and establish whether they can be used prospectively to guide treatment. 

Characterising and targeting the treatment resistant population in B-ALL following Inotuzumab Ozogamicin treatment

MYB-directed therapy for paediatric AML

Development of CCR9-targeting antibody therapy for paediatric T-cell acute lymphoblastic leukaemia

Equipping CAR T-cells with IL-12 to achieve durable tumour responses in neuroblastoma

Radiotherapy-induced neurocognitive deficits in medulloblastoma: Human-equivalent modelling and randomised pre-clinical trials to identify effective pharmacological interventions for clinical application