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Developing a reliable, potentially life-saving test for Constitutional Mismatch Repair Deficiency

Identification of MSH6 null individuals in patients suspected of suffering from Constitutional Mismatch Repair Cancer Syndrome

Dr Ian Carr, Leeds Institutes of Molecular Medicine, University of Leeds,

Development of ‘seek and destroy’ system against neuroblastoma

Development of GD2-specific Bi-specific T-cell Engagers (BiTEs) for treatment of neuroblastoma

Dr Karin Straathof, Institute of Child Health, University College London

Developing models to test new drug treatments for childhood leukaemia

Pre-clinical drug validation in acute lymphoid and myeloid leukaemia

Dr Owen Williams, Institute of Child Health, University College London

Developing immunotherapy for childhood sarcomas

Developing GD2-targeted cellular immunotherapy for childhood sarcomas

Professor John Anderson, Institute of Child Health, University College London

Aiming to reduce side-effects when treating children with leukaemia

Investigate the utility of vincristine pharmacokinetic and pharmacogenetic biomarkers to predict MRD status and toxicity in children with acute lymphoblastic leukaemia

Dr Sujith Samarasinghe, Great Ormond Street Hospital

Childhood cancer immunotherapy using blood cells from umbilical cord blood

T cell receptor gene therapy: novel strategies for children with cancer using engineered cord blood T cells

Professor Waseem Qasim, UCL Institute of Child Health

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