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Increasing the effectiveness of radiotherapy for children with neuroblastoma

Increasing the susceptibility of neuroblastoma cells to radiotherapy by targeting glycolysis and lipogenesis

Professor Anthony Chalmers, Wolfson Wohl Cancer Research Centre, University of Glasgow

Discovery, development, and delivery of effective combination therapies for high-risk medulloblastoma

INSTINCT-MB: Strategic implementation of novel combination therapeutics for high-risk medulloblastoma

Professor Steve Clifford, Newcastle University Centre for Cancer, Newcastle University

Identifying novel targeted therapies for acute lymphoblastic leukaemia

Targeting RUNX/Core Binding Factor-dependency in relapsed and poor prognosis acute lymphoblastic leukaemia

Professor Tariq Enver, UCL Cancer Institute

Immunotherapy for infant and childhood MLL-rearranged acute lymphoblastic leukaemia

Improving immunotherapies for the treatment of leukaemia

Dr Anindita Roy and Professor Anastasios Karadimitris, University of Oxford and Imperial College London

Relapse-specific therapeutic vulnerability evaluation in childhood and young adult ALL (REVEALL)

Improving outcomes for children whose leukaemia relapses after treatment

Dr David O’Connor, Professor Marc Mansour and Dr Jack Bartram, University College London Cancer Institute and Great Ormond Street Institute of Child Health

Getting ahead of drug resistance in diffuse midline glioma (including diffuse intrinsic pontine glioma)

Evolutionary dynamics of MEK inhibitor sensitivity and resistance in diffuse midline glioma

Prof. Chris Jones, Institute of Cancer Research

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